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Metabolic Syndrome (MS) has been correlated to breast carcinogenesis. MS is common in the general population (34%) and increases with age and body mass index. Although the link between obesity, MS and hormone related cancer incidence is now widely recognized, the molecular mechanisms at the basis of such increase are still poorly characterized. A crucial role is supposed to be played by the altered insulin signalling, occurring in obese patients, which fuels cancer cell growth, proliferation and survival. Therefore we focused specifically on insulin resistance to investigate clinically the potential role of insulin in breast carcinogenesis. 975 patients were enrolled and the association between MS, insulin resistance, and breast cancer was evaluated. Women were stratified by age and menopausal status. Insulin resistance was measured through the Homeostasis Model Assessment score (HOMA-IR). The cut …
BioMed Central
Publication date: 
1 Dec 2013

Immacolata Capasso, Emanuela Esposito, Francesca Pentimalli, Maurizio Montella, Anna Crispo, Nicola Maurea, Massimiliano D’Aiuto, Alfredo Fucito, Maria Grimaldi, Ernesta Cavalcanti, Giuseppe Esposito, Giuseppe Brillante, Sergio Lodato, Tonino Pedicini, Giuseppe D’Aiuto, Gennaro Ciliberto, Antonio Giordano

Biblio References: 
Volume: 32 Issue: 1 Pages: 1-6
Journal of Experimental & Clinical Cancer Research