Within the tight-binding approximation, we study the dependence of the electronic band structure and of the optical conductivity of a graphene single layer on the modulus and direction of applied uniaxial strain. While the Dirac-cone approximation, albeit with a deformed cone, is robust for sufficiently small strain, band dispersion linearity breaks down along a given direction, corresponding to the development of anisotropic massive low-energy excitations. We recover a linear behavior of the low-energy density of states, as long as the cone approximation holds, while a band gap opens for sufficiently intense strain, for almost all, generic strain directions. This may be interpreted in terms of an electronic topological transition, corresponding to a change in topology of the Fermi line, and to the merging of two inequivalent Dirac points as a function of strain. We propose that these features may be observed in the frequency …