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Background: From the beginning of 2020, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) quickly spread worldwide, becoming the main problem for the healthcare systems. Healthcare workers (HCWs) are at higher risk of infection and can be a dangerous vehicle for the spread of the virus. Furthermore, cancer patients (CPs) are a vulnerable population, with an increased risk of developing severe and lethal forms of Coronavirus Disease 19 (COVID-19). Therefore, at the National Cancer Institute of Naples, where only cancer patients are treated, a surveillance program aimed to prevent the hospital access of SARS-CoV-2 positive subjects (HCWs and CPs) was implemented. The study aims to describe the results of the monitoring activity for the SARS-CoV-2 spread among HCWs and CPs, from March 2020 to March 2021. Methods: This surveillance program included a periodic sampling through nasopharyngeal molecular swabs for SARS-CoV-2 (Real-Time Polymerase Chain Reaction, RT-PCR). CPs were submitted to the molecular test at least 48 h before hospital admission. Survival analysis and multiple logistic regression models were performed among HCWs and CPs to assess the main SARS-CoV-2 risk factors. Results: The percentages of HCWs tested with RT-PCR for the detection of SARS-CoV-2, according to the first and the second wave, were 79.7% and 91.7%, respectively, while the percentages for the CPs were 24.6% and 39.6%. SARS-CoV-2 was detected in 20 (1.7%) HCWs of the 1204 subjects tested during the first wave, and in 127 (9.2%) of 1385 subjects tested in the second wave (p < 0.001); among CPs …
Publication date: 
20 Jan 2022

Anna Crispo, Piergiacomo Di Gennaro, Sergio Coluccia, Sara Gandini, Concetta Montagnese, Giuseppe Porciello, Flavia Nocerino, Maria Grimaldi, Mariangela Tafuri, Assunta Luongo, Emanuela Rotondo, Alfonso Amore, Francesco Labonia, Serena Meola, Stefanie Marone, Giovanni Pierro, Simona Menegozzo, Leonardo Miscio, Francesco Perri, Maurizio Rainisio, Attilio AM Bianchi, Ernesta Cavalcanti, Marco Cascella, Egidio Celentano

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Volume: 10 Issue: 2 Pages: 205